Ontology highlight
ABSTRACT:
SUBMITTER: Hong W
PROVIDER: S-EPMC7367443 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Hong Weihao W Cheng Wenzhao W Zheng Tingjin T Jiang Nan N Xu Ruian R
PLoS pathogens 20200717 7
Establishing latent infection but retaining the capability to reactivate in certain circumstance is an ingenious tactic for retroviruses to persist in vivo while evading host immune surveillance. Many evidences indicate that Human T-cell leukemia virus type 1 (HTLV-1) is not completely silent in vivo. However, signals that trigger HTLV-1 latency-reactivation switching remain poorly understood. Here, we show that aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, plays a cr ...[more]