Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC7368199 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Yang Zhilu Z Zhao Xin X Hao Rui R Tu Qiufen Q Tian Xiaohua X Xiao Yu Y Xiong Kaiqing K Wang Miao M Feng Yonghai Y Huang Nan N Pan Guoqing G
Proceedings of the National Academy of Sciences of the United States of America 20200629 28
Thrombogenic reaction, aggressive smooth muscle cell (SMC) proliferation, and sluggish endothelial cell (EC) migration onto bioinert metal vascular stents make poststenting reendothelialization a dilemma. Here, we report an easy to perform, biomimetic surface engineering strategy for multiple functionalization of metal vascular stents. We first design and graft a clickable mussel-inspired peptide onto the stent surface via mussel-inspired adhesion. Then, two vasoactive moieties [i.e., the nitric ...[more]