S-EPMC7368987 - Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. - OmicsDI

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Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry.

ABSTRACT: BACKGROUND:The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). METHODS:A total of 1143 subjects (aged 60.7?±?9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm3) at follow-up minus PV at index?>?0. Annual change of PV (mm3/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100)???1.0%/year. RESULTS:The median inter-scan period was 3.2 (range 2.6-4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0-117.7), group II: 47.2 (6.2-160.4), and group III [highest]: 57.5 (8.4-154.3); P?

SUBMITTER: Won KB

PROVIDER: S-EPMC7368987 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry.

Won Ki-Bum KB Lee Byoung Kwon BK Park Hyung-Bok HB Heo Ran R Lee Sang-Eun SE Rizvi Asim A Lin Fay Y FY Kumar Amit A Hadamitzky Martin M Kim Yong-Jin YJ Sung Ji Min JM Conte Edoardo E Andreini Daniele D Pontone Gianluca G Budoff Matthew J MJ Gottlieb Ilan I Chun Eun Ju EJ Cademartiri Filippo F Maffei Erica E Marques Hugo H de Araújo Gonçalves Pedro P Leipsic Jonathon A JA Shin Sanghoon S Choi Jung Hyun JH Virmani Renu R Samady Habib H Chinnaiyan Kavitha K Raff Gilbert L GL Stone Peter H PH Berman Daniel S DS Narula Jagat J Shaw Leslee J LJ Bax Jeroen J JJ Min James K JK Chang Hyuk-Jae HJ

Cardiovascular diabetology 20200718 1

<h4>Background</h4>The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA).<h4>Methods</h4>A total of 1143 subjects (aged 60.7 ± 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque D ...[more]

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