Ontology highlight
ABSTRACT:
SUBMITTER: Lian J
PROVIDER: S-EPMC7369031 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Lian Jeffrey J Ozga Aleksandra J AJ Sokol Caroline L CL Luster Andrew D AD
Cell reports 20200501 8
Generating robust CD4<sup>+</sup> T-helper cell type 1 (Th1) responses is essential for protective vaccine-induced type 1 immunity. Here, we examine whether immunization formulation associated with enhanced vaccine efficacy promotes antigen targeting and cell recruitment into lymph node (LN) niches associated with optimal type 1 responses. Immunization with antigen and Toll-like receptor agonist emulsified in oil leads to an increased differentiation of IFNγ/TNF-α<sup>+</sup> polyfunctional Th1 ...[more]