Novel NIR modeling design and assignment in process quality control of Honeysuckle flower by QbD.

ABSTRACT: Honeysuckle flower is a common edible-medicinal food with significant anti-inflammatory efficacy. Process quality control of its ethanol precipitation is a topical issue in the pharmaceutical field. Near infrared (NIR) spectroscopy is commonly used for process quality analysis. However, establishing a robust and reliable quantitative model of complex process remains a challenge in industrial applications of NIR. In this paper, modeling design based on quality by design concept (QbD) was implemented for the ethanol precipitation process quality control of Honeysuckle flower. According to the 56 models' performances and 25 contour plots, quadratic model was the best with R_adj² increasing from 0.1395 to 0.9085, indicating the strong interaction among spectral pre-process

SUBMITTER: Ma L 

PROVIDER: S-EPMC7369169 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature