Ontology highlight
ABSTRACT:
SUBMITTER: Scheuer R
PROVIDER: S-EPMC7370021 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Scheuer Rebecca R Philipp Stephan Ernst SE Becker Alexander A Nalbach Lisa L Ampofo Emmanuel E Montenarh Mathias M Götz Claudia C
International journal of molecular sciences 20200630 13
The regulation of insulin biosynthesis and secretion in pancreatic β-cells is essential for glucose homeostasis in humans. Previous findings point to the highly conserved, ubiquitously expressed serine/threonine kinase CK2 as having a negative regulatory impact on this regulation. In the cell culture model of rat pancreatic β-cells INS-1, insulin secretion is enhanced after CK2 inhibition. This enhancement is preceded by a rise in the cytosolic Ca<sup>2+</sup> concentration. Here, we identified ...[more]