Ontology highlight
ABSTRACT:
SUBMITTER: Syed SN
PROVIDER: S-EPMC7370080 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200702 13
Recent studies suggested an important contribution of sphingosine-1-phospate (S1P) signaling via its specific receptors (S1PRs) in the production of pro-inflammatory mediators such as Interleukin (IL)-1β in cancer and inflammation. In an inflammation-driven cancer setting, we previously reported that myeloid S1PR1 signaling induces IL-1β production by enhancing NLRP3 (NOD-, LRR- and Pyrin Domain-Containing Protein 3) inflammasome activity. However, the autocrine role of S1P and enzymes acting on ...[more]