Ontology highlight
ABSTRACT:
SUBMITTER: Hantschel O
PROVIDER: S-EPMC7370805 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Hantschel Oliver O Biancalana Matthew M Koide Shohei S
Current opinion in structural biology 20200201
Monobodies, built with the scaffold of the fibronectin type III domain, are among the most well-established synthetic binding proteins. They promote crystallization of challenging molecular systems. They have strong tendency to bind to functional sites and thus serve as drug-like molecules that perturb the biological functions of their targets. Monobodies lack disulfide bonds and thus they are particularly suited as genetically encoded reagents to be used intracellularly. This article reviews re ...[more]