Passenger Hotspot Mutations in Cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Hess JM
PROVIDER: S-EPMC7371346 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Passenger Hotspot Mutations in Cancer.
Hess Julian M JM Bernards Andre A Kim Jaegil J Miller Mendy M Taylor-Weiner Amaro A Haradhvala Nicholas J NJ Lawrence Michael S MS Getz Gad G
Cancer cell 20190901 3
Current statistical models for assessing hotspot significance do not properly account for variation in site-specific mutability, thereby yielding many false-positives. We thus (i) detail a Log-normal-Poisson (LNP) background model that accounts for this variability in a manner consistent with models of mutagenesis; (ii) use it to show that passenger hotspots arise from all common mutational processes; and (iii) apply it to a ∼10,000-patient cohort to nominate driver hotspots with far fewer false ...[more]
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