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Antipsychotic treatment experiences of people with bipolar I disorder: patient perspectives from an online survey.

ABSTRACT: BACKGROUND:Oral antipsychotic (AP) medications are frequently prescribed to people with bipolar I disorder (BD-I). A cross-sectional online survey examined the experiences of people living with BD-I with a history of recent AP use. METHODS:Adults with self-reported physician-diagnosed BD-I (N =?200) who received oral APs during the prior year completed a survey on AP-related experiences, including side effects and their perceived burden on social functioning, adherence, and work. Items also assessed preferences for trade-offs (balancing symptom management and side effects) when considering a hypothetical new AP. The perceived impact of specific, prevalent side effects on adherence, work, and preferences for a hypothetical AP were also examined. Analyses were descriptive. RESULTS:The survey sample had a mean age of 43.2 (SD?=?12.4) years, was 60% female, and 31% nonwhite. Almost all participants (98%) had experienced AP side effects. Common self-reported side effects were feeling drowsy or tired (83%), lack of emotion (79%), anxiety (79%), dry mouth (76%), and weight gain (76%). Weight gain was cited as the most bothersome side effect, rated by most participants (68%) as "very" or "extremely bothersome." Nearly half of participants (49%) reported that AP side effects negatively impacted their job performance; almost all (92%) reported that side effects - most commonly anxiety and lack of emotion - negatively impacted social relationships (e.g., family or romantic partners). The most commonly-reported reason for stopping AP use was dislike of side effects (48%). Side effects most likely to lead to stopping or taking less of AP treatment included "feeling like a 'zombie'" (29%), feeling drowsy or tired (25%), and weight gain (24%). When considering a hypothetical new AP, the most common side effects participants wanted to avoid included AP-induced anxiety (50%), weight gain (48%), and "feeling like a 'zombie'" (47%). CONCLUSIONS:Side effects of APs were both common and bothersome, and impacted social functioning, adherence, and work. Findings highlight the prevailing unmet need for new APs with more favorable benefit-risk profiles.

SUBMITTER: Bessonova L

PROVIDER: S-EPMC7371473 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Antipsychotic treatment experiences of people with bipolar I disorder: patient perspectives from an online survey.

Bessonova Leona L Velligan Dawn I DI Weiden Peter J PJ O'Sullivan Amy K AK Yarlas Aaron A Bayliss Martha M Baranwal Nishtha N Rychlec Kaitlin K Carpenter-Conlin Julia J Doane Michael J MJ Sajatovic Martha M

BMC psychiatry 20200706 1

<h4>Background</h4>Oral antipsychotic (AP) medications are frequently prescribed to people with bipolar I disorder (BD-I). A cross-sectional online survey examined the experiences of people living with BD-I with a history of recent AP use.<h4>Methods</h4>Adults with self-reported physician-diagnosed BD-I (N = 200) who received oral APs during the prior year completed a survey on AP-related experiences, including side effects and their perceived burden on social functioning, adherence, and work. ...[more]

PMID: 32631362

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Dataset Information

Antipsychotic treatment experiences of people with bipolar I disorder: patient perspectives from an online survey.

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Antipsychotic treatment experiences of people with bipolar I disorder: patient perspectives from an online survey.

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