Ontology highlight
ABSTRACT:
SUBMITTER: Shen Z
PROVIDER: S-EPMC7371600 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Shen Zongshan Z Kuang Shuhong S Zhang Yong Y Yang Mingmei M Qin Wei W Shi Xuetao X Lin Zhengmei Z
Bioactive materials 20200716 4
Periodontitis is caused by host immune-inflammatory response to bacterial insult. A high proportion of pro-inflammatory macrophages to anti-inflammatory macrophages leads to the pathogenesis of periodontitis. As stem cell-derived exosomes can modulate macrophage phenotype, dental pulp stem cell-derived exosomes (DPSC-Exo) can effectively treat periodontitis. In this study, we demonstrated that DPSC-Exo-incorporated chitosan hydrogel (DPSC-Exo/CS) can accelerate the healing of alveolar bone and t ...[more]