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Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes.


ABSTRACT: OBJECTIVE:To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]). RESULTS:Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (P = 0.014) were observed. CONCLUSIONS:Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.

SUBMITTER: Suput Omladic J 

PROVIDER: S-EPMC7372055 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes.

Šuput Omladič Jasna J   Slana Ozimič Anka A   Vovk Andrej A   Šuput Dušan D   Repovš Grega G   Dovc Klemen K   Bratina Nataša N   Avbelj Stefanija Magdalena M   Battelino Tadej T  

Diabetes care 20200529 8


<h4>Objective</h4>To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D).<h4>Research design and methods</h4>Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]).<h4>Results</h4>Lower spatial wo  ...[more]

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