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ABSTRACT: Objective
To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D).Research design and methods
Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]).Results
Lower spatial working memory (sWM) capacity during acute hyperglycemia and significant differences in activation of regions of interest during different stages of the sWM task (P = 0.014) were observed.Conclusions
Acute hyperglycemia negatively affected sWM capacity in adolescents with T1D, which is relevant for daily functioning and academic performance.
SUBMITTER: Suput Omladic J
PROVIDER: S-EPMC7372055 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Šuput Omladič Jasna J Slana Ozimič Anka A Vovk Andrej A Šuput Dušan D Repovš Grega G Dovc Klemen K Bratina Nataša N Avbelj Stefanija Magdalena M Battelino Tadej T
Diabetes care 20200529 8
<h4>Objective</h4>To investigate the effect of acute hyperglycemia on brain function in adolescents with type 1 diabetes (T1D).<h4>Research design and methods</h4>Twenty participants with T1D (aged 14.64 ± 1.78 years) and 20 age-matched healthy control subjects (aged 14.40 ± 2.82 years) performed two functional MRI sessions. Participants with T1D performed the first scanning session under euglycemic and the second under hyperglycemic clamp (20 mmol/L [360 mg/dL]).<h4>Results</h4>Lower spatial wo ...[more]