Genetic underpinnings of cerebral edema in acute brain injury: an opportunity for pathway discovery.

ABSTRACT: Cerebral edema constitutes an important contributor to secondary injury in acute brain injury. The quantification of cerebral edema in neuroimaging, a well-established biomarker of secondary brain injury, represents a useful intermediate phenotype to study edema formation. Population genetics provides powerful tools to identify novel susceptibility genes, biological pathways and therapeutic targets related to brain edema formation. Here, we provide an overview of the pathogenesis of cerebral edema, introduce relevant genetic methods to study this process, and discuss the ongoing research on the genetic underpinnings of edema formation in acute brain injury. The epsilon 2 and 4 variants within the Apolipoprotein E (APOE) gene are associated with worse outcome after traumatic brain injury an

SUBMITTER: Kirsch E 

PROVIDER: S-EPMC7372633 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature