Enhanced Intracranial Microdialysis by Reduction of Traumatic Penetration Injury at the Probe Track.
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ABSTRACT:
SUBMITTER: Varner EL
PROVIDER: S-EPMC7372793 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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Enhanced Intracranial Microdialysis by Reduction of Traumatic Penetration Injury at the Probe Track.
Varner Erika L EL Jaquins-Gerstl Andrea A Michael Adrian C AC
ACS chemical neuroscience 20160404 6
Microdialysis provides deep insight into chemical neuroscience by enabling in vivo intracranial chemical monitoring. Nevertheless, implanting a microdialysis probe causes a traumatic penetration injury (TPI) of brain tissue at the probe track. The TPI, which is clearly documented by voltammetry and histochemical imaging, is a drawback because it perturbs the exact tissue from which the brain dialysate samples are derived. Our goal is to reduce, if not eventually eliminate, the TPI and its detrim ...[more]
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