An Ayurvedic Perspective along with in Silico Study of the Drugs for the Management of Sars-Cov-2.

ABSTRACT:

Background

Covid-19 is the disease caused by SARS-CoV2, it was identified in Wuhan, China, in 2019. It then extended across the globe and was termed as a pandemic in 2020. Though research work on its vaccine and drugs are carried out across the globe, it is even necessary to look over it through alternative sciences.

Objective

The objective of this study is to look over the disease through Ayurvedic perspective, analyse possible pathologies, select appropriate drugs and to study in-silico screening on these selected drugs.Materials & Methods: Available symptoms of Covid 19 were thoroughly studied and reviewed through Ayurveda classics, internet, preprints, etc. to understand the nature of the disease with the Ayurvedic perspective.The molecular Docking and Grid were generated through Pyrx Software with Autodock. The Lipinski Rule of Five data generated from Swiss ADME software and Target prediction of selected phytoconstituents were done by Swiss target prediction.

Results

and Discussion: In Ayurveda, Covid19 can be considered as Janapadaudhwans, Vaat-Kaphaj Sannipatik Jwara, Aupsargika Vyadhi, and Dhatupaka Awastha. In the molecular docking study, the binding energy and inhibition of 6 Gingesulphonic acid from Zingiber Officinalis (Sunthi) is greater than hydroxychloroquine and quinine. Most of the selected phytoconstituents follow the Lipinski rule of five. Target prediction of selected phytoconstituents was done on target of SARS-COV-2, humoral immunity, and antiviral activity. Every selected phytoconstituents works on minimum one of the targets.

Conclusion

Thus, from the above results obtained from reviewing Ayurveda classics and after the virtual screening of selected drugs we can conclude that Nagaraadi Kashaya(Sunthi, Puskarmoola, Kantakari, Guduchi) may have appreciable results in combating SARS-COV-2. Thus, Nagaraadi Kashayam, a classical formulation can be a trial candidate for conducting further clinical trial.

SUBMITTER: Gandhi AJ 

PROVIDER: S-EPMC7373022 | biostudies-literature |

REPOSITORIES: biostudies-literature