A comprehensive method protocol for annotation and integrated functional understanding of lncRNAs.
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ABSTRACT:
SUBMITTER: Kunz M
PROVIDER: S-EPMC7373182 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
A comprehensive method protocol for annotation and integrated functional understanding of lncRNAs.
Kunz Meik M Wolf Beat B Fuchs Maximilian M Christoph Jan J Xiao Ke K Thum Thomas T Atlan David D Prokosch Hans-Ulrich HU Dandekar Thomas T
Briefings in bioinformatics 20200701 4
Long non-coding RNAs (lncRNAs) are of fundamental biological importance; however, their functional role is often unclear or loosely defined as experimental characterization is challenging and bioinformatic methods are limited. We developed a novel integrated method protocol for the annotation and detailed functional characterization of lncRNAs within the genome. It combines annotation, normalization and gene expression with sequence-structure conservation, functional interactome and promoter ana ...[more]
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