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No effect of test and treat on sexual behaviours at population level in rural South Africa.


ABSTRACT: CONTEXT:Within the community-randomized ANRS 12249 Treatment-as-Prevention trial conducted in rural South Africa, we analysed sexual behaviours stratified by sex over time, comparing immediate antiretroviral therapy irrespective of CD4+ cell count vs. CD4+-guided antiretroviral therapy (start at CD4+?cell count?>?350 cells/?l then >500 cells/?l) arms. METHODS:As part of the 6-monthly home-based trial rounds, a sexual behaviour individual questionnaire was administered to all residents at least 16 years. We considered seven indicators: sexual intercourse in the past month; at least one regular sexual partner in the past 6 months; at least one casual sexual partner in the past 6 months and more than one sexual partner in the past 6 months; condom use at last sex (CLS) with regular partner, CLS with casual partner, and point prevalence estimate of concurrency. We conducted repeated cross-sectional analyses, stratified by sex. Generalized Estimating Equations models were used, including trial arm, trial time, calendar time and interaction between trial arm and trial time. RESULTS:CLS with regular partner varied between 29-51% and 23-46% for men and women, respectively, with significantly lower odds among women in the control vs. intervention arm by trial end (P?

SUBMITTER: Rolland M 

PROVIDER: S-EPMC7373441 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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No effect of test and treat on sexual behaviours at population level in rural South Africa.

Rolland Matthieu M   McGrath Nuala N   Tiendrebeogo Thierry T   Larmarange Joseph J   Pillay Deenan D   Dabis François F   Orne-Gliemann Joanna J  

AIDS (London, England) 20190301 4


<h4>Context</h4>Within the community-randomized ANRS 12249 Treatment-as-Prevention trial conducted in rural South Africa, we analysed sexual behaviours stratified by sex over time, comparing immediate antiretroviral therapy irrespective of CD4+ cell count vs. CD4+-guided antiretroviral therapy (start at CD4+ cell count > 350 cells/μl then >500 cells/μl) arms.<h4>Methods</h4>As part of the 6-monthly home-based trial rounds, a sexual behaviour individual questionnaire was administered to all resid  ...[more]

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