Impact of tacrolimus versus cyclosporin A on renal function during the first year after heart transplant.

ABSTRACT:

Aims

Nephrotoxicity of calcineurin inhibitors (CNIs) is associated with adverse events in patients undergoing heart transplant (HTx), although studies directly comparing tacrolimus (TAC) versus cyclosporin A (CsA), especially in combination with everolimus and low-dose CNIs approach, are limited. Thus, we sought to investigate the associations of TAC and CsA with clinical outcomes in HTx recipients, with specific focus on renal function.

Methods and results

From August 2007 to February 2017, 72 consecutive patients (39 treated with TAC vs. 33 with CsA) receiving de novo HTx in a single transplant centre were retrospectively evaluated. We used the instrumental variable method to account for unmeasured confounding. The study outcomes were percentage change in estimated glomeru

SUBMITTER: Shiraishi Y 

PROVIDER: S-EPMC7373882 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature