Majority sensing in synthetic microbial consortia.
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ABSTRACT:
SUBMITTER: Alnahhas RN
PROVIDER: S-EPMC7374166 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Majority sensing in synthetic microbial consortia.
Alnahhas Razan N RN Sadeghpour Mehdi M Chen Ye Y Frey Alexis A AA Ott William W Josić Krešimir K Bennett Matthew R MR
Nature communications 20200721 1
As synthetic biocircuits become more complex, distributing computations within multi-strain microbial consortia becomes increasingly beneficial. However, designing distributed circuits that respond predictably to variation in consortium composition remains a challenge. Here we develop a two-strain gene circuit that senses and responds to which strain is in the majority. This involves a co-repressive system in which each strain produces a signaling molecule that signals the other strain to down-r ...[more]
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