Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention.
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ABSTRACT: Development of improved approaches for HIV-1 prevention will likely be required for a durable end to the global AIDS pandemic. Recent advances in preclinical studies and early phase clinical trials offer renewed promise for immunologic strategies for blocking acquisition of HIV-1 infection. Clinical trials are currently underway to evaluate the efficacy of two vaccine candidates and a broadly neutralizing antibody (bNAb) to prevent HIV-1 infection in humans. However, the vast diversity of HIV-1 is a major challenge for both active and passive immunization. Here we review current immunologic strategies for HIV-1 prevention, with a focus on current and next-generation vaccines and bNAbs.
SUBMITTER: Stephenson KE
PROVIDER: S-EPMC7375352 | biostudies-literature |
REPOSITORIES: biostudies-literature
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