Ontology highlight
ABSTRACT:
SUBMITTER: Paunovska K
PROVIDER: S-EPMC7375820 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Paunovska Kalina K Da Silva Sanchez Alejandro A Da Silva Sanchez Alejandro A Foster Matthew T MT Loughrey David D Blanchard Emmeline L EL Islam Fatima Z FZ Gan Zubao Z Mantalaris Athanasios A Santangelo Philip J PJ Dahlman James E JE
Science advances 20200722 30
The biological pathways that affect drug delivery in vivo remain poorly understood. We hypothesized that altering cell metabolism with phosphatidylinositol (3,4,5)-triphosphate (PIP3), a bioactive lipid upstream of the metabolic pathway PI3K (phosphatidylinositol 3-kinase)/AKT/ mTOR (mammalian target of rapamycin) would transiently increase protein translated by nanoparticle-delivered messenger RNA (mRNA) since these pathways increase growth and proliferation. Instead, we found that PIP3 blocked ...[more]