Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states.

ABSTRACT: This review describes and summarizes the role of neuronal nitric oxide synthase (nNOS) on the central nervous system, particularly on brain regions such as the ventrolateral medulla (VLM) and the periaqueductal gray matter (PAG), and on blood vessels and the heart that are involved in the regulation and control of the cardiovascular system (CVS). Furthermore, we shall also review the functional aspects of nNOS during several physiological, pathophysiological, and clinical conditions such as exercise, pain, cerebral vascular accidents or stroke and hypertension. For example, during stroke, a cascade of molecular, neurochemical, and cellular changes occur that affect the nervous system as elicited by generation of free radicals and nitric oxide (NO) from vulnerable neurons, peroxide formatio

SUBMITTER: Ally A 

PROVIDER: S-EPMC7375925 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature