Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi N
PROVIDER: S-EPMC7376092 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20200722 1
Early diagnosis of dementia including Alzheimer's disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene, which encodes coenzyme A synthase, were increased in individuals with AD and amnestic mild cognitive impairment (aMCI). The present study sought to replicate these findings with larger numbers of samples. Another objective was to clarify whether COASY methylation is assoc ...[more]