Ontology highlight
ABSTRACT:
SUBMITTER: Leclere PS
PROVIDER: S-EPMC7376252 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Leclère Pierre S PS Rousseau Déborah D Patouraux Stéphanie S Guérin Sophie S Bonnafous Stéphanie S Gréchez-Cassiau Aline A Ruberto Anthony A AA Luci Carmelo C Subramaniam Malayannan M Tran Albert A Delaunay Franck F Gual Philippe P Teboul Michèle M
Scientific reports 20200722 1
A large number of hepatic functions are regulated by the circadian clock and recent evidence suggests that clock disruption could be a risk factor for liver complications. The circadian transcription factor Krüppel like factor 10 (KLF10) has been involved in liver metabolism as well as cellular inflammatory and death pathways. Here, we show that hepatic steatosis and inflammation display diurnal rhythmicity in mice developing steatohepatitis upon feeding with a methionine and choline deficient d ...[more]