Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins.

ABSTRACT:

Objective

To study the development of children conceived from non-IVF infertility treatments consisting of gonadotropins, clomiphene, or letrozole.

Design

Prospective cohort study.

Setting

U.S. academic health centers.

Patient(s)

Children of women with polycystic ovary syndrome who conceived with letrozole (LTZ) or clomiphene (CC) in the PPCOS II study or women with unexplained infertility (AMIGOS study) who conceived with LTZ, CC, or gonadotropin (GN).

Intervention(s)

Longitudinal annual follow-up from birth to age 3.

Main outcome measure(s)

Scores from Ages and Stages Developmental Questionnaire (ASQ), MacArthur-Bates Communicative Development Inventory (MCDI), and annual growth.

Result(s)

One hundred eighty-five children from 160 familie

SUBMITTER: Legro RS 

PROVIDER: S-EPMC7376442 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature