Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC7376544 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20200120 9
Antimicrobial proteins such as S100A12 and S100A8/A9 are highly expressed and secreted by neutrophils during infection and participate in human immune response by sequestering transition metals. At neutral pH, S100A12 sequesters Zn<sup>2+</sup> with nanomolar affinity, which is further enhanced upon calcium binding. We investigated the pH dependence of human S100A12 zinc sequestration by using Co<sup>2+</sup> as a surrogate. Apo-S100A12 exhibits strong Co<sup>2+</sup> binding between pH 7.0 and ...[more]