Ontology highlight
ABSTRACT:
SUBMITTER: Chang W
PROVIDER: S-EPMC7377265 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Chang Wenhan W Tu Chia-Ling CL Jean-Alphonse Frederic G FG Herberger Amanda A Cheng Zhiqiang Z Hwong Jenna J Ho Hanson H Li Alfred A Wang Dawei D Liu Hongda H White Alex D AD Suh Insoo I Shen Wen W Duh Quan-Yang QY Khanafshar Elham E Shoback Dolores M DM Xiao Kunhong K Vilardaga Jean-Pierre JP
Nature metabolism 20200309 3
Molecular mechanisms mediating tonic secretion of parathyroid hormone (PTH) in response to hypocalcaemia and hyperparathyroidism (HPT) are unclear. Here we demonstrate increased heterocomplex formation between the calcium-sensing receptor (CaSR) and metabotropic γ-aminobutyric acid (GABA) B<sub>1</sub> receptor (GABA<sub>B1</sub>R) in hyperplastic parathyroid glands (PTGs) of patients with primary and secondary HPT. Targeted ablation of GABA<sub>B1</sub>R or glutamic acid decarboxylase 1 and 2 i ...[more]