Ontology highlight
ABSTRACT:
SUBMITTER: Rosshart SP
PROVIDER: S-EPMC7377314 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Rosshart Stephan P SP Herz Jasmin J Vassallo Brian G BG Hunter Ashli A Wall Morgan K MK Badger Jonathan H JH McCulloch John A JA Anastasakis Dimitrios G DG Sarshad Aishe A AA Leonardi Irina I Collins Nicholas N Blatter Joshua A JA Han Seong-Ji SJ Tamoutounour Samira S Potapova Svetlana S Foster St Claire Mark B MB Yuan Wuxing W Sen Shurjo K SK Dreier Matthew S MS Hild Benedikt B Hafner Markus M Wang David D Iliev Iliyan D ID Belkaid Yasmine Y Trinchieri Giorgio G Rehermann Barbara B
Science (New York, N.Y.) 20190801 6452
Laboratory mouse studies are paramount for understanding basic biological phenomena but also have limitations. These include conflicting results caused by divergent microbiota and limited translational research value. To address both shortcomings, we transferred C57BL/6 embryos into wild mice, creating "wildlings." These mice have a natural microbiota and pathogens at all body sites and the tractable genetics of C57BL/6 mice. The bacterial microbiome, mycobiome, and virome of wildlings affect th ...[more]