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Preclinical characterization of CPL302-253, a selective inhibitor of PI3K?, as the candidate for the inhalatory treatment and prevention of Asthma.

ABSTRACT: Asthma is a common chronic inflammatory disease. Although effective asthma therapies are available, part of asthmatic population do not respond to these treatment options. In this work we present the result of development of CPL302-253 molecule, a selective PI3K? inhibitor. This molecule is intended to be a preclinical candidate for dry powder inhalation in asthma treatment. Studies we performed showed that this molecule is safe and effective PI3K? inhibitor that can impact many immune functions. We developed a short, 15-day HDM induced asthma mouse model, in which we showed that CPL302-253 is able to block inflammatory processes leading to asthma development in vivo.

SUBMITTER: Gunerka P

PROVIDER: S-EPMC7377474 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Preclinical characterization of CPL302-253, a selective inhibitor of PI3Kδ, as the candidate for the inhalatory treatment and prevention of Asthma.

Gunerka Paweł P Gala Kamila K Banach Martyna M Dominowski Jakub J Hucz-Kalitowska Joanna J Mulewski Krzysztof K Hajnal Agnes A Mikus Endre G EG Smuga Damian D Zagozda Marcin M Dubiel Krzysztof K Pieczykolan Jerzy J Zygmunt Beata M BM Wieczorek Maciej M

PloS one 20200723 7

Asthma is a common chronic inflammatory disease. Although effective asthma therapies are available, part of asthmatic population do not respond to these treatment options. In this work we present the result of development of CPL302-253 molecule, a selective PI3Kδ inhibitor. This molecule is intended to be a preclinical candidate for dry powder inhalation in asthma treatment. Studies we performed showed that this molecule is safe and effective PI3Kδ inhibitor that can impact many immune functions ...[more]

PMID: 32702053

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