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Maintaining social contacts: The physiological relevance of organelle interactions.

ABSTRACT: Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate and facilitate cellular functions. The formation of close contacts, termed "membrane contact sites" (MCSs), represents an intriguing strategy for organelle interaction and coordinated interplay. Emerging research is rapidly revealing new details of MCSs. They represent ubiquitous and diverse structures, which are important for many aspects of cell physiology and homeostasis. Here, we provide a comprehensive overview of the physiological relevance of organelle contacts. We focus on mitochondria, peroxisomes, the Golgi complex and the plasma membrane, and discuss the most recent findings on their interactions with other subcellular organelles and their multiple functions, including membrane contacts with the ER, lipid droplets and the endosomal/lysosomal compartment.

SUBMITTER: Silva BSC

PROVIDER: S-EPMC7377706 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Maintaining social contacts: The physiological relevance of organelle interactions.

Silva Beatriz S C BSC DiGiovanni Laura L Kumar Rechal R Carmichael Ruth E RE Kim Peter K PK Schrader Michael M

Biochimica et biophysica acta. Molecular cell research 20200723 11

Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate and facilitate cellular functions. The formation of close contacts, termed "membrane contact sites" (MCSs), represents an intriguing strategy for organelle interaction and coordinated interplay. Emerging research is rapidly revealing new details of MCSs. They represent ubiquitous and diverse structures, which are important for many aspects of cell physiology and homeostasis. Here, we provide a comprehensive o ...[more]

PMID: 32712071

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