Dataset Information

How Does the Delta-Radiomics Better Differentiate Pre-Invasive GGNs From Invasive GGNs?

ABSTRACT: Purpose: This study aimed to explore the role of delta-radiomics in differentiating pre-invasive ground-glass nodules (GGNs) from invasive GGNs, compared with radiomics signature. Materials and Methods: A total of 464 patients including 107 pre-invasive GGNs and 357 invasive GGNs were embraced in radiomics signature analysis. 3D regions of interest (ROIs) were contoured with ITK software. By means of ANOVA/MW, correlation analysis, and LASSO, the optimal radiomic features were selected. The logistic classifier of radiomics signature was constructed and radiomic scores (rad-scores) were calculated. A total of 379 patients including 48 pre-invasive GGNs and 331 invasive GGNs with baseline and follow-up CT examinations before surgeries were enrolled in delta-radiomics analysis. Finally, the logistic classifier of delta-radiomics was constructed. The receiver operating characteristic curves (ROCs) were built to evaluate the validity of classifiers. Results: For radiomics signature analysis, six features were selected from 396 radiomic features. The areas under curve (AUCs) of logistic classifiers were 0.865 (95% CI, 0.823-0.900) in the training set and 0.800 (95% CI, 0.724-0.863) in the testing set. The rad-scores of invasive GGNs were larger than those of pre-invasive GGNs. As the follow-up interval went on, more and more delta-radiomic features became statistically different. The AUC of the delta-radiomics logistic classifier was 0.901 (95% CI, 0.867-0.928), which was higher than that of the radiomics signature. Conclusion: The radiomics signature contributes to distinguish pre-invasive and invasive GGNs. The rad-scores of invasive GGNs were larger than those of pre-invasive GGNs. More and more delta-radiomic features appeared to be statistically different as follow-up interval prolonged. Delta-radiomics is superior to radiomics signature in differentiating pre-invasive and invasive GGNs.

SUBMITTER: Ma Y

PROVIDER: S-EPMC7378390 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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How Does the Delta-Radiomics Better Differentiate Pre-Invasive GGNs From Invasive GGNs?

Ma Yanqing Y Ma Weijun W Xu Xiren X Cao Fang F

Frontiers in oncology 20200716

<b>Purpose:</b> This study aimed to explore the role of delta-radiomics in differentiating pre-invasive ground-glass nodules (GGNs) from invasive GGNs, compared with radiomics signature. <b>Materials and Methods:</b> A total of 464 patients including 107 pre-invasive GGNs and 357 invasive GGNs were embraced in radiomics signature analysis. 3D regions of interest (ROIs) were contoured with ITK software. By means of ANOVA/MW, correlation analysis, and LASSO, the optimal radiomic features were sele ...[more]

PMID: 32766129

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Project description:PURPOSE:This study aimed to investigate the effectiveness of using delta-radiomics to predict overall survival (OS) for patients with recurrent malignant gliomas treated by concurrent stereotactic radiosurgery and bevacizumab, and to investigate the effectiveness of machine learning methods for delta-radiomics feature selection and building classification models. METHODS:The pre-treatment, one-week post-treatment, and two-month post-treatment T1 and T2 fluid-attenuated inversion recovery (FLAIR) MRI were acquired. 61 radiomic features (intensity histogram-based, morphological, and texture features) were extracted from the gross tumor volume in each image. Delta-radiomics were calculated between the pre-treatment and post-treatment features. Univariate Cox regression and 3 multivariate machine learning methods (L1-regularized logistic regression [L1-LR], random forest [RF] or neural networks [NN]) were used to select a reduced number of features, and 7 machine learning methods (L1-LR, L2-LR, RF, NN, kernel support vector machine [KSVM], linear support vector machine [LSVM], or naïve bayes [NB]) was used to build classification models for predicting OS. The performances of the total 21 model combinations built based on single-time-point radiomics (pre-treatment, one-week post-treatment, and two-month post-treatment) and delta-radiomics were evaluated by the area under the receiver operating characteristic curve (AUC). RESULTS:For a small cohort of 12 patients, delta-radiomics resulted in significantly higher AUC than pre-treatment radiomics (p-value<0.01). One-week/two-month delta-features resulted in significantly higher AUC (p-value<0.01) than the one-week/two-month post-treatment features, respectively. 18/21 model combinations were with higher AUC from one-week delta-features than two-month delta-features. With one-week delta-features, RF feature selector + KSVM classifier and RF feature selector + NN classifier showed the highest AUC of 0.889. CONCLUSIONS:The results indicated that delta-features could potentially provide better treatment assessment than single-time-point features. The treatment assessment is substantially affected by the time point for computing the delta-features and the combination of machine learning methods for feature selection and classification.

Dataset Information

How Does the Delta-Radiomics Better Differentiate Pre-Invasive GGNs From Invasive GGNs?

Publications

How Does the Delta-Radiomics Better Differentiate Pre-Invasive GGNs From Invasive GGNs?

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