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CT lung lesions as predictors of early death or ICU admission in COVID-19 patients.


ABSTRACT: OBJECTIVE:The main objective of this study was to investigate the prognostic value of early systematic chest computed tomography (CT) with quantification of lung lesions in coronavirus disease 2019 (COVID-19) patients. METHODS:We studied 572 patients diagnosed with COVID-19 (confirmed using polymerase chain reaction) for whom a chest CT was performed at hospital admission. Visual quantification was used to classify patients as per the percentage of lung parenchyma affected by COVID-19 lesions: normal CT, 0-10%, 11-25%, 26-50%, 51-75% and >75%. The primary endpoint was severe disease, defined by death or admission to the intensive care unit in the 7 days following first admission. RESULTS:The mean patient age was 66.0 ± 16.0 years, and 343/572 (60.0%) were men. The primary endpoint occurred in 206/572 patients (36.0%). The extent of lesions on initial CT was independently associated with prognosis (odds ratio = 2.35, 95% confidence interval 1.24-4.46; p < 0.01). Most patients with lung involvement >50% (66/95, 69.5%) developed severe disease compared to patients with lung involvement of 26-50% (70/171, 40.9%) and ?25% (70/306, 22.9%) (p < 0.01 and p < 0.01, respectively). None of the patients with normal CT (0/14) had severe disease. CONCLUSION:Chest CT findings at admission are associated with outcome in COVID-19 patients.

SUBMITTER: Ruch Y 

PROVIDER: S-EPMC7378475 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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CT lung lesions as predictors of early death or ICU admission in COVID-19 patients.

Ruch Yvon Y   Kaeuffer Charlotte C   Ohana Mickael M   Labani Aissam A   Fabacher Thibaut T   Bilbault Pascal P   Kepka Sabrina S   Solis Morgane M   Greigert Valentin V   Lefebvre Nicolas N   Hansmann Yves Y   Danion François F  

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20200724 10


<h4>Objective</h4>The main objective of this study was to investigate the prognostic value of early systematic chest computed tomography (CT) with quantification of lung lesions in coronavirus disease 2019 (COVID-19) patients.<h4>Methods</h4>We studied 572 patients diagnosed with COVID-19 (confirmed using polymerase chain reaction) for whom a chest CT was performed at hospital admission. Visual quantification was used to classify patients as per the percentage of lung parenchyma affected by COVI  ...[more]

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