Polygenic risk and pleiotropy in neurodegenerative diseases.
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ABSTRACT:
SUBMITTER: Bellou E
PROVIDER: S-EPMC7378564 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Polygenic risk and pleiotropy in neurodegenerative diseases.
Bellou Eftychia E Stevenson-Hoare Joshua J Escott-Price Valentina V
Neurobiology of disease 20200520
In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD). We summarize the various techniques developed to investigate pleiotropy among traits, elaborating in the polygenic risk scores (PRS) analysis. PRS was designed to assess a cumulative effect of a large number of SNPs for association with a disease and, later for disease risk prediction. Since genetic predictions rely on heritability, we discuss SNP-based heritability from gen ...[more]
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