MicroRNA Profiling in Wilms Tumor: Identification of Potential Biomarkers.

ABSTRACT: Wilms tumor (WT) is the most frequently diagnosed malignant renal tumor in children. With current treatments, ~90% of children diagnosed with WT survive and generally present with tumors characterized by favorable histology (FHWT), whereas prognosis is poor for the remaining 10% of cases where the tumors are characterized by cellular diffuse anaplasia (DAWT). Relatively few studies have investigated microRNA-related epigenetic regulation and its relationship with altered gene expression in WT. Here, we aim to identify microRNAs differentially expressed in WT and describe their expression in terms of cellular anaplasia, metastasis, and association with the main genetic alterations in WT to identify potential prognostic biomarkers. Expression profiling using TaqMan low-density array was perf

SUBMITTER: Perez-Linares FJ 

PROVIDER: S-EPMC7378594 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature