Ontology highlight
ABSTRACT:
SUBMITTER: Acharya KS
PROVIDER: S-EPMC7378842 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20200723 1
As marijuana legalization is increasing, research regarding possible long-term risks for users and their offspring is needed. Little data exists on effects of paternal tetrahydrocannabinol (THC) exposure prior to reproduction. This study determined if chronic THC exposure alters sperm DNA methylation (DNAm) and if such effects are intergenerationally transmitted. Adult male rats underwent oral gavage with THC or vehicle control. Differentially methylated (DM) loci in motile sperm were identified ...[more]