Ontology highlight
ABSTRACT:
SUBMITTER: Ishikawa W
PROVIDER: S-EPMC7378855 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Ishikawa Wataru W Kikuchi Satoru S Ogawa Toshihiro T Tabuchi Motoyasu M Tazawa Hiroshi H Kuroda Shinji S Noma Kazuhiro K Nishizaki Masahiko M Kagawa Shunsuke S Urata Yasuo Y Fujiwara Toshiyoshi T
Molecular therapy oncolytics 20200625
Peritoneal metastasis is the most frequent form of distant metastasis and recurrence in gastric cancer, and the prognosis is extremely poor due to the resistance of systemic chemotherapy. Here, we demonstrate that intraperitoneal (i.p.) administration of a green fluorescence protein (GFP)-expressing attenuated adenovirus with oncolytic potency (OBP-401) synergistically suppressed the peritoneal metastasis of gastric cancer in combination with paclitaxel (PTX). OBP-401 synergistically suppressed ...[more]