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Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?


ABSTRACT: Severe acute respiratory syndrome coronavirus 2 causes the potentially fatal coronavirus disease 2019 (COVID-19). Already during the outbreak of the severe acute respiratory syndrome coronavirus 1, the use of vitamin C was suggested. Many patients with severe COVID-19 have elevated levels of the mediators interleukin-6 and endothelin-1. These mediators may explain the age dependence of COVID-19 pneumonia, the preponderance of male and obese or hypertensive patients, as well as of persons of color and smokers. There is clear evidence that vitamin C in high doses can reduce these mediators. Vitamin C is cheap and safe. Hence, using a relatively low dose of vitamin C as prophylaxis, and in cases of severe COVID-19, an (intravenous) high-dose regimen may be beneficial. Ongoing clinical trials are expected to provide more definitive evidence.

SUBMITTER: Feyaerts AF 

PROVIDER: S-EPMC7381407 | biostudies-literature | 2020 Nov - Dec

REPOSITORIES: biostudies-literature

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Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?

Feyaerts Adam F AF   Luyten Walter W  

Nutrition (Burbank, Los Angeles County, Calif.) 20200725


Severe acute respiratory syndrome coronavirus 2 causes the potentially fatal coronavirus disease 2019 (COVID-19). Already during the outbreak of the severe acute respiratory syndrome coronavirus 1, the use of vitamin C was suggested. Many patients with severe COVID-19 have elevated levels of the mediators interleukin-6 and endothelin-1. These mediators may explain the age dependence of COVID-19 pneumonia, the preponderance of male and obese or hypertensive patients, as well as of persons of colo  ...[more]

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