Single oral dose for HIV pre or post-exposure prophylaxis: user desirability and biological efficacy in macaques.

ABSTRACT:

Background

Daily oral pre- or post-exposure prophylaxis (PrEP or PEP) is highly effective in preventing HIV infection. However, many people find it challenging to adhere to a daily oral regimen. Chemoprophylaxis with single oral doses of antiretroviral drugs taken before or after sex may better adapt to changing or unanticipated sexual practices and be a desirable alternative to daily PrEP or PEP. We investigated willingness to use a single oral pill before or after sex among men who have sex with men (MSM) and assessed the biological efficacy of a potent antiretroviral combination containing elvitegravir (EVG), emtricitabine (FTC), and tenofovir alafenamide (TAF).

Methods

Data on willingness to use single-dose PrEP or PEP were obtained from the 2017 cycle of the American Me

SUBMITTER: Massud I 

PROVIDER: S-EPMC7381488 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature