Ontology highlight
ABSTRACT:
SUBMITTER: Caillot M
PROVIDER: S-EPMC7381668 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Caillot M M Bourgeais J J Dakik H H Costé É É Mazure N M NM Lelièvre É É Coqueret O O Hérault O O Mazurier F F Sola B B
Oncogenesis 20200724 7
Cancer cells are characterized by the Warburg effect, a shift from mitochondrial respiration to oxidative glycolysis. We report here the crucial role of cyclin D1 in promoting this effect in a cyclin-dependent kinase (CDK)4/6-independent manner in multiple myeloma (MM) cells. We show that the cyclin D1 oncoprotein targets hexokinase 2 (HK2), a major glycolysis regulator, through two original molecular mechanisms in the cytoplasmic and nuclear compartments. In the cytoplasm, cyclin D1 binds HK2 a ...[more]