Ontology highlight
ABSTRACT:
SUBMITTER: Bennett NR
PROVIDER: S-EPMC7382022 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Bennett Nitasha R NR Jarvis Cassie M CM Alam Mohammad Murshid MM Zwick Daniel B DB Olson Jake M JM Nguyen Hung V-T HV Johnson Jeremiah A JA Cook Mark E ME Kiessling Laura L LL
Biomacromolecules 20191111 12
Subunit vaccines can have excellent safety profiles, but their ability to give rise to robust immune responses is often compromised. For glycan-based vaccines, insufficient understanding of B and T cell epitope combinations that yield optimal immune activation hinders optimization. To determine which antigen features promote desired IgG responses, we synthesized epitope-functionalized polymers using ring-opening metathesis polymerization (ROMP) and assessed the effect of B and T cell epitope loa ...[more]