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Noninvasive acoustic manipulation of objects in a living body.

ABSTRACT: In certain medical applications, transmitting an ultrasound beam through the skin to manipulate a solid object within the human body would be beneficial. Such applications include, for example, controlling an ingestible camera or expelling a kidney stone. In this paper, ultrasound beams of specific shapes were designed by numerical modeling and produced using a phased array. These beams were shown to levitate and electronically steer solid objects (3-mm-diameter glass spheres), along preprogrammed paths, in a water bath, and in the urinary bladders of live pigs. Deviation from the intended path was on average <10%. No injury was found on the bladder wall or intervening tissue.

SUBMITTER: Ghanem MA

PROVIDER: S-EPMC7382215 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Noninvasive acoustic manipulation of objects in a living body.

Ghanem Mohamed A MA Maxwell Adam D AD Wang Yak-Nam YN Cunitz Bryan W BW Khokhlova Vera A VA Sapozhnikov Oleg A OA Bailey Michael R MR

Proceedings of the National Academy of Sciences of the United States of America 20200706 29

In certain medical applications, transmitting an ultrasound beam through the skin to manipulate a solid object within the human body would be beneficial. Such applications include, for example, controlling an ingestible camera or expelling a kidney stone. In this paper, ultrasound beams of specific shapes were designed by numerical modeling and produced using a phased array. These beams were shown to levitate and electronically steer solid objects (3-mm-diameter glass spheres), along preprogramm ...[more]

PMID: 32631991

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