Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC7382266 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Li Bing B Nguyen Thao Phuong TP Ma Chenyan C Dan Yang Y
Proceedings of the National Academy of Sciences of the United States of America 20200706 29
The prefrontal cortex (PFC) plays a critical role in curbing impulsive behavior, but the underlying circuit mechanism remains incompletely understood. Here we show that a subset of dorsomedial PFC (dmPFC) layer 5 pyramidal neurons, which project to the subthalamic nucleus (STN) of the basal ganglia, play a key role in inhibiting impulsive responses in a go/no-go task. Projection-specific labeling and calcium imaging showed that the great majority of STN-projecting neurons were preferentially act ...[more]