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Association between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population.


ABSTRACT: Interleukin-6 (IL6) is encoded by the IL6 gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that IL6 substantially contribute in the diagnosed of systemic in?ammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the protagonist of IL6 (-174 G/C) genotypes as an essential risk factor for COPD in north Indian population. In the study, a total of 200 clinically diagnosed patients with COPD were selected against 200 patients. Statistical analysis reveleaed that there was no significant association between the IL6 -174 G/C genetic polymorphism and the risk of COPD (P>0.05).

SUBMITTER: Kirtipal N 

PROVIDER: S-EPMC7382402 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Association between <i>IL6</i> gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population.

Kirtipal Nikhil N   Thakur Hitender H   Sobti Ranbir Chander RC   Janmeja Ashok Kumar AK  

Molecular biology research communications 20200601 2


Interleukin-6 (IL6) is encoded by the <i>IL6</i> gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that <i>IL6</i> substantially contribute in the diagnosed of systemic inflammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the protagonist of <i>IL6</i> (-174 G/C) genotypes as an essential risk factor for COPD in north Indian population.  ...[more]

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