Ontology highlight
ABSTRACT:
SUBMITTER: Liao R
PROVIDER: S-EPMC7382780 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Liao Ruiqi R Zheng Ye Y Liu Xin X Zhang Yuannyu Y Seim Gretchen G Tanimura Nobuyuki N Wilson Gary M GM Hematti Peiman P Coon Joshua J JJ Fan Jing J Xu Jian J Keles Sunduz S Bresnick Emery H EH
Cell reports 20200601 13
Protein ensembles control genome function by establishing, maintaining, and deconstructing cell-type-specific chromosomal landscapes. A plethora of small molecules orchestrate cellular functions and therefore may link physiological processes with genome biology. The metabolic enzyme and hemoglobin cofactor heme induces proteolysis of a transcriptional repressor, Bach1, and regulates gene expression post-transcriptionally. However, whether heme controls genome function broadly or through prescrip ...[more]