Unknown

Dataset Information

0

PhysIOpathology of NEuromuscular function rElated to fatigue in chronic Renal disease in the elderly (PIONEER): study protocol.


ABSTRACT: BACKGROUND:Chronic Kidney Disease (CKD) is associated with reduced muscular strength resulting in profound fatigue. The physiopathology of these changes, their prevalence and evolution are still debated. Moreover, we have little data on elderly CKD patients. The present study protocol aims to 1) quantify the prevalence of low muscle strength (dynapenia) in a cohort of elderly patients with advanced CKD and to 2) characterize their force production coupled with electromyographic features and the symptoms of fatigue compared to a matched control group. METHODS:This is a case-control, prospective, interventional study. INCLUSION CRITERIA:age???60?years; CKD Stage 3b-5; clinical stability (i.e. no hospitalization and???25% in creatinine increase in the previous 3?months). Controls with normal kidney function will be matched in terms of age, gender and diabetes mellitus (requisite: estimated glomerular filtration rate???60?ml/min/1.73m2 available in the last 6?months). Exclusion criteria for cases and controls: neuromuscular disease, life expectancy

SUBMITTER: Chatrenet A 

PROVIDER: S-EPMC7382847 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

PhysIOpathology of NEuromuscular function rElated to fatigue in chronic Renal disease in the elderly (PIONEER): study protocol.

Chatrenet Antoine A   Beaune Bruno B   Fois Antioco A   Pouliquen Camille C   Audebrand Jean-Michel JM   Torreggiani Massimo M   Paris Damien D   Durand Sylvain S   Piccoli Giorgina Barbara GB  

BMC nephrology 20200725 1


<h4>Background</h4>Chronic Kidney Disease (CKD) is associated with reduced muscular strength resulting in profound fatigue. The physiopathology of these changes, their prevalence and evolution are still debated. Moreover, we have little data on elderly CKD patients. The present study protocol aims to 1) quantify the prevalence of low muscle strength (dynapenia) in a cohort of elderly patients with advanced CKD and to 2) characterize their force production coupled with electromyographic features  ...[more]

Similar Datasets

| S-EPMC4948885 | biostudies-literature
| S-EPMC8088125 | biostudies-literature
| S-EPMC5803288 | biostudies-literature
| S-EPMC4274817 | biostudies-other
| S-EPMC8388284 | biostudies-literature
| S-EPMC4411708 | biostudies-literature
| S-EPMC1326206 | biostudies-literature
| S-EPMC6266418 | biostudies-literature
| S-EPMC5700439 | biostudies-literature
| S-EPMC6051500 | biostudies-literature