Ontology highlight
ABSTRACT:
SUBMITTER: An IB
PROVIDER: S-EPMC7383507 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
An In Bok IB Byun Mi Sun MS Yang Sang In SI Choi Yuri Y Woo Jung Won JW Jang Hak Chul HC Sung Young Chul YC
Diabetes, obesity & metabolism 20200603 8
<h4>Aim</h4>To evaluate the pharmacokinetic and pharmacodynamic properties of a novel glycosylated Fc-fused glucagon-like peptide-1(GLP-1-gFc) receptor agonist with distinctive receptor binding affinity, designed to improve in vivo stability and safety relative to the commercial GLP-1 analogue dulaglutide, and assess its safety profile and pharmacokinetics in healthy humans.<h4>Materials and methods</h4>We constructed GLP-1-gFc and determined its binding affinity and potency using in vitro instr ...[more]