Placental fatty acid transport across late gestation in a baboon model of intrauterine growth restriction.

ABSTRACT:

Key points

Intrauterine growth restriction (IUGR) is associated with perinatal morbidity and increased risk of lifelong disease, including neurodevelopmental impairment. Fatty acids (FA) are critical for normal brain development, although their transport across the placenta in IUGR pregnancies is poorly understood. The present study used a baboon model of IUGR (maternal nutrient restriction, MNR) to investigate placental expression of FA transport and binding proteins, and to determine gestational age-related changes in maternal and fetal plasma FA concentrations. We found MNR to be associated with increased placental expression of FA binding and transport proteins in late gestation, with fetal plasma FA concentrations that were similar to those of control animals. The present stud

SUBMITTER: Chassen SS 

PROVIDER: S-EPMC7384518 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature