Ontology highlight
ABSTRACT:
SUBMITTER: Ries LNA
PROVIDER: S-EPMC7384679 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Ries Laure N A LNA Pardeshi Lakhansing L Dong Zhiqiang Z Tan Kaeling K Steenwyk Jacob L JL Colabardini Ana Cristina AC Ferreira Filho Jaire A JA de Castro Patricia A PA Silva Lilian P LP Preite Nycolas W NW Almeida Fausto F de Assis Leandro J LJ Dos Santos Renato A C RAC Bowyer Paul P Bromley Michael M Owens Rebecca A RA Doyle Sean S Demasi Marilene M Hernández Diego C R DCR Netto Luís Eduardo S LES Pupo Monica T MT Rokas Antonis A Loures Flavio V FV Wong Koon H KH Goldman Gustavo H GH
PLoS pathogens 20200715 7
Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which contribute to enhancing fungal fitness and growth within the mammalian host. Gliotoxin (GT) is a SM that interferes with the function and recruitment of innate immune cells, which are essential for eliminating A. fumigatus during invasive infections. We identified a C6 Zn cluster-type transcription factor (TF), subsequently named RglT, impo ...[more]