Integration of Hydrogel Microparticles With Three-Dimensional Liver Progenitor Cell Spheroids.

ABSTRACT: The study of the liver progenitor cell microenvironment has demonstrated the important roles of both biochemical and biomechanical signals in regulating the progenitor cell functions that underlie liver morphogenesis and regeneration. While controllable two-dimensional in vitro culture systems have provided key insights into the effects of growth factors and extracellular matrix composition and mechanics on liver differentiation, it remains unclear how microenvironmental signals may differentially affect liver progenitor cell responses in a three-dimensional (3D) culture context. In addition, there have only been limited efforts to engineer 3D culture models of liver progenitor cells through the tunable presentation of microenvironmental stimuli. We present an in vitro model of 3D liver pr

SUBMITTER: Gentile SD 

PROVIDER: S-EPMC7385057 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature