Unknown

Dataset Information

0

Age-dependent regional retinal nerve fibre changes in SIX1/SIX6 polymorphism.

ABSTRACT: SIX1/SIX6 polymorphism has been shown to be associated with glaucoma. Studies have also found that, in older adults, retinal nerve fibre layer (RNFL) thickness is significantly thinned with each copy of the risk allele in SIX1/SIX6. However, it is not known whether these genetic variants exert their effects in younger individuals. Comparing a healthy young adult with an older adult cohort (mean age 20 vs 63 years), both of Northern European descent, we found that there was no significant RNFL thinning in each copy of the risk alleles in SIX1/SIX6 in the eyes of younger individuals. The older cohort showed an unexpectedly thicker RNFL in the nasal sector with each copy of the risk allele for both the SIX1 (rs10483727) and SIX6 (rs33912345) variants. In the temporal sector, thinner RNFL was found with each copy of the risk allele in rs33912345 with a decrease trend observed in rs10483727. Our results suggest that SIX1/SIX6 gene variants exert their influence later in adult life.

SUBMITTER: Charng J 

PROVIDER: S-EPMC7385166 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Age-dependent regional retinal nerve fibre changes in SIX1/SIX6 polymorphism.

Charng Jason J   Simcoe Mark M   Sanfilippo Paul G PG   Allingham R Rand RR   Hewitt Alex W AW   Hammond Chris J CJ   Mackey David A DA   Yazar Seyhan S  

Scientific reports 20200727 1

SIX1/SIX6 polymorphism has been shown to be associated with glaucoma. Studies have also found that, in older adults, retinal nerve fibre layer (RNFL) thickness is significantly thinned with each copy of the risk allele in SIX1/SIX6. However, it is not known whether these genetic variants exert their effects in younger individuals. Comparing a healthy young adult with an older adult cohort (mean age 20 vs 63 years), both of Northern European descent, we found that there was no significant RNFL th  ...[more]

Similar Datasets

Unknown Association of SIX1/SIX6 locus polymorphisms with regional circumpapillary retinal nerve fibre layer thickness: The Nagahama study.
| S-EPMC5491508 | biostudies-literature
Unknown Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent.
| S-EPMC4509729 | biostudies-literature
Unknown Changes in retinal nerve fibre layer, optic nerve head morphology, and visual field after acute primary angle closure.
| S-EPMC3171266 | biostudies-other
Unknown Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age.
| S-EPMC8858642 | biostudies-literature
Unknown Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint.
| S-EPMC5392743 | biostudies-literature
Unknown Retinal nerve fibre layer thinning and corneal nerve loss in patients with Bardet-Biedl syndrome.
| S-EPMC10666305 | biostudies-literature
Unknown Association of common SIX6 polymorphisms with peripapillary retinal nerve fiber layer thickness: the Singapore Chinese Eye Study.
| S-EPMC4544593 | biostudies-literature
Unknown Retinal nerve fibre layer thickness floor and corresponding functional loss in glaucoma.
| S-EPMC4441828 | biostudies-literature
Unknown Association between localised retinal nerve fibre layer defects and cardiovascular risk factors.
| S-EPMC6920147 | biostudies-literature
Unknown Retinal nerve fibre layer thinning is associated with drug resistance in epilepsy.
| S-EPMC4819648 | biostudies-literature